The Mixed Committee of the FAMHP (which examines the ‘grey zone’ products) has issued a new guideline regarding the use of D-mannose in food supplements.
Products with an amount of D-mannose higher than 750 mg/day can have a significant physiological effect. Therefore, a maximum of 750 mg of D-mannose per day are allowed in food supplements (higher doses fall under the definition of medicines).
In addition, no allusions should be made to any therapeutic properties of D-mannose, in particular UTIs (urinary tract infections). In that case, even products with less than 750 mg of D-mannose can be considered as medicines.
Since this is a guideline and no legal text, this is a legally non-binding advice.
Source: Grijze zone | FAGG